Phosphatase tensin-type domain

WebIPR014020 - Tensin_phosphatase_C2-dom Pfam Domains: PF08416 - Phosphotyrosine-binding domain PF10409 - C2 domain of PTEN tumour-suppressor protein PF00017 - SH2 … WebMMAC1 phosphatase and tensin homolog deleted on chromosome 10 antibody; Mutated in multiple advanced cancers 1 antibody; Phosphatase and tensin homolog antibody; …

ZFIN Gene: ptenb - Zebrafish Information Network

WebMar 1, 2024 · β-Amyloid Precursor Protein Intracellular Domain Controls Mitochondrial Function by Modulating Phosphatase and Tensin Homolog-Induced Kinase 1 Transcription in Cells and in Alzheimer Mice Models Overall, we delineate a molecular cascade presenilins-AICD-Forkhead box O3a linking parkin to Pink-1. WebEnables lipid phosphatase activity. Acts upstream of or within several processes, including lifelong otolith mineralization; negative regulation of angiogenesis; and phosphatidylinositol dephosphorylation. Predicted to be located in PML body and cytoplasm. how comfortable is the oculus quest 2 https://alicrystals.com

Gene Variant Detail

WebPTEN H93Y lies within the phosphatase tensin-type domain of the Pten protein (UniProt.org). H93Y demonstrates loss of phosphatase activity ( PMID: 10866302 , PMID: … WebContains 1 phosphatase tensin-type domain. 结构域 The C2 domain binds phospholipid membranes in vitro in a Ca(2+)-independent manner; this binding is important for its tumor suppressor function. WebChain A, Tensin-like C1 domain-containing phosphatase (human) Protein Target - PubChem Apologies, we are having some trouble retrieving data from our servers... PUGVIEW … how comfy is a spring bed with box spings

Gene Variant Detail

Category:Anti-PTEN antibody (ab31392) Abcam

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Phosphatase tensin-type domain

Phosphatase - an overview ScienceDirect Topics

WebGene Variant Descriptions. PTEN H93Q lies within the phosphatase tensin-type domain of the Pten protein (UniProt.org). H93Q demonstrates Pten protein stability similar to wild-type protein ( PMID: 32350270, PMID: 32366478 ), however, results in a partial loss of ability to rescue spheroid formation ( PMID: 32366478 ), fails to suppress Akt ... Webphosphatase and tensin homolog, b-catenin, p53, endometrial carcinoma. C ancer of the uterine corpus is the most common gynecologic malignancy in the U.S., with approximately 40,880 cases diag-nosed in 2006.1 The incidence of endometrial carcinoma (EC) also has risen each year in Japan over 30 years from 10% in 1983 to 45%

Phosphatase tensin-type domain

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WebJan 2, 2024 · Phosphatase and tensin homolog deleted on chromosome 10 ( PTEN ) encodes a 403-amino acid protein with an amino-terminal domain that shares sequence … WebSMART: PTEN_C2 domain annotation PTEN_C2 C2 domain of PTEN tumour-suppressor protein There are 6056 PTEN_C2 domains in 6045 proteins in SMART's nrdb database. Click on the following links for more information. Evolution (species in which this domain is found) Cellular role (predicted cellular role) Structure (3D structures containing this domain)

WebPhosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchanger factor 2 (PREX2) is a novel regulator of the small guanosine triphosphatase Rac, and has been observed to be implicated in human cancer by inhibiting the activity of phosphatase and tensin homolog (PTEN), thus upregulating the activity of the phosphoinositide 3-kinase (PI3K) signaling …

WebMar 28, 1997 · In preliminary screens, mutations of PTEN were detected in 31% (13/42) of glioblastoma cell lines and xenografts, 100% (4/4) of prostate cancer cell lines, 6% (4/65) … WebMar 21, 2024 · TNS3 (Tensin 3) is a Protein Coding gene. Diseases associated with TNS3 include Thyroid Tumor and Primary Syphilis . Among its related pathways are MET promotes cell motility and Signaling by Receptor Tyrosine Kinases . Gene Ontology (GO) annotations related to this gene include phosphatase activity . An important paralog of this gene is …

WebJan 2, 2024 · Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) encodes a 403-amino acid protein with an amino-terminal domain that shares sequence homology with the actin-binding protein tensin and the putative tyrosine-protein phosphatase auxilin.Crystal structure analysis of PTEN has revealed a C2 domain that binds to …

WebFeb 17, 2024 · Tensin was first reported in 1991 as an actin-binding focal-adhesion protein containing a Src homology 2 (SH2) domain, a newly identified binding motif specific for phosphotyrosine (pTyr) at the time, suggesting an interesting role of tensin in bridging signal transduction pathways with the cytoskeletal networks ( Davis et al., 1991 ). how comfy is the cordaroy beanbag chairWebDescription: Homo sapiens transmembrane phosphatase with tensin homology (TPTE), transcript variant 1, mRNA. (from RefSeq NM_199261) RefSeq Summary (NM_199261): … how many portions of oils and spreads a dayWebMar 1, 2001 · Protein PHOSPHATASE AND TENSIN HOMOLOG 1 1 publication ( AtPTEN1 1 publication ) Gene names Name PTEN1 1 publication ORF names MUL8.80 Imported Ordered locus names At5g39400 Imported Organism names Organism Arabidopsis thaliana (Mouse-ear cress) Taxonomic identifier 3702 NCBI Taxonomic lineage how many portions of fruit and veg per dayPhosphatase and tensin homolog (PTEN) is a phosphatase in humans and is encoded by the PTEN gene. Mutations of this gene are a step in the development of many cancers, specifically glioblastoma, lung cancer, breast cancer, and prostate cancer. Genes corresponding to PTEN (orthologs) have been … See more PTEN protein acts as a phosphatase to dephosphorylate phosphatidylinositol (3,4,5)-trisphosphate (PtdIns (3,4,5)P3 or PIP3). PTEN specifically catalyses the dephosphorylation of the 3` phosphate of the See more The structure of the core of PTEN (solved by X-ray crystallography, see figure to the upper right ) reveals that it consists primarily of a phosphatase domain, and a C2 domain: the phosphatase domain contains the active site, which carries out the See more PTEN inhibitors Bisperoxovanadium compounds may have a neuroprotective effect after CNS injury. PTEN is inhibited by See more PTEN (gene) has been shown to interact with: • CSNK2A2, • CSNK2A1, • MAGI3 • MVP, • NEDD4, See more Cancer PTEN is one of the most commonly lost tumor suppressors in human cancer; in fact, up to 70% of men with prostate cancer are estimated to have lost a copy of the PTEN gene at the time of diagnosis. A number of studies … See more Cell lines with known PTEN mutations include: • prostate: LNCaP, PC-3 • kidney: 786-O • glioblastoma: U87MG • breast : MB-MDA-468, BT549 See more • Multiple hamartoma syndrome See more how many portions of rice should we eat a dayWebJul 5, 2005 · Domain: 431-573: C2 tensin-type InterPro annotation. BLAST Add. ... PTHR12305 PHOSPHATASE WITH HOMOLOGY TO TENSIN 1 hit; PTHR12305:SF60 … how many portions of vegetables a dayWeb1 day ago · This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a … how comfy is the nissan rouge driver seatWebContains 1 phosphatase tensin-type domain. Domain. The C2 domain binds phospholipid membranes in vitro in a Ca(2+)-independent manner; this binding is important for its tumor suppressor function. Post-translational modifications. Constitutively phosphorylated by CK2 under normal conditions. Phosphorylated in vitro by MAST1, MAST2, MAST3 and STK11. how many portlands are there in the usa