Webb1 feb. 2024 · It was found that, changing the solvent from nitromethane to 1,2-dichloroethane, was beneficial for the reaction outcome. Specifically, when PhI(OPiv) 2 was employed as oxidant, both 1a and 1b could be efficiently converted into the desired products 3a and 3b in 86 and 80% yields, respectively (Table 2, entries 1 and 2). WebbFurthermore, Thompson et al. reported the preparation of cyclic ethers 27 via Pd-catalyzed oxime masked-alcohol directed dehydrogenative annulation of sp 3 C–H bonds of substrates 26 using PhI(OAc) 2 1 as an oxidant (Thompson et al., 2015).The reaction occurs selectively at the β-position and substrates 26 having primary, secondary, and …
Supporting Information - Royal Society of Chemistry
WebbArylsilanes 55 reacts in the presence of hypervalent iodine(III) reagents PhI(OAc) 2 1 or PhI(OPiv) 2 56 in 1,2-dichloroethane (DCE) to yield monoacetoxylated or pivaloxylated products 57 in a good yield . Both of the hypervalent iodine(III) reagents act as oxidants as well as the source of the acyloxyl group. WebbSN2’path is observed with organocopper reagents, 4 whereas 30 oxygen-centered nucleophiles,5 halogens6 and sulfur-stabilized carbanions,3,7 lead preferentially to S N2 products. The latter examples suggest that the regioselectivity of the ring opening reactions of vinylaziridines is governed mainly by the type of nucleophile. total budget cost formula
cas 1239669-07-8, C 20 H 21 (2) H 2 NO 5 S Articles data …
WebbAn oxidative C−H amination of 8‐acylaminoquinolines and anilides with N‐fluorobenzenesulfonimide (NFSI) has been developed. This process was mediated by a hypervalent iodine reagent PhI(OPiv) 2 under mild reaction conditions without any metallic catalyst or oxidant. The protocol showed good air and moisture tolerance, functional … WebbA mild, metal-free synthesis of pyrido[1,2-a]benzimidazoles starting with N-benzyl-2-aminopyridines, which employs PhI(OPiv) 2 as a stoichiometric oxidant, has been developed. The process is initiated by an unusual PhI(OPiv) 2-mediated ipso S E Ar reaction, followed by solvent-assisted C-C and C-N bond cleavage. View More WebbPreparation of Zn(OPiv) 2 Pivalic acid (20.4 g, 22.6 mL, 200 mmol) was placed in a dry and argon-flushed 500 mL three-necked round-bottom flask, equipped with a magnetic stirring bar, a septum and a pressure equalizer, and was dissolved in dry THF (120 mL). The mixture was cooled at 0 °C, total budgeted overhead formula