Circhif1a
WebJun 3, 2024 · Posttranscriptional tRNA modifications are essential for proper gene expression, and defects in the enzymes that perform tRNA modifications ar ... WebChen, T., Wang, X., Li, C., Zhang, H., Liu, Y., Han, D., … Yang, Q. (2024). CircHIF1A regulated by FUS accelerates triple-negative breast cancer progression by ...
Circhif1a
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WebHIF1A. Hypoxia-inducible factor 1-alpha, also known as HIF-1-alpha, is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 ( HIF-1) that is encoded by the HIF1A gene. [5] [6] [7] The Nobel Prize in … WebMechanistically, circHIF1A modulated the expression and translocation of NFIB through posttranscriptional and posttranslational modifications, resulting in the activation of the …
First, we constructed a circHIF1A overexpression plasmid and designed two small interfering RNAs (siRNAs) targeting the splicing junction of circHIF1A. CircHIF1A overexpression and knockdown efficiencies in TNBC were validated by qRT-PCR (Supplementary Fig. 2A). The expression levels of linear HIF1A … See more Fused in sarcoma (FUS) belongs to the FET family of ubiquitously expressed RNA-binding proteins involved in multiple stages of RNA processing [30, 31]. Recently, FUS was … See more Interestingly, we found that ectopic expression of NFIB could increase circHIF1A expression, while NFIB knockdown led to … See more Because the potential roles of FUS in TNBC progression are largely unknown, we conducted functional experiments with FUS overexpression … See more WebMini-Circuits. Manufacturer Product Number. PHA-1+. Description. IC RF AMP CATV 50MHZ-6GHZ SOT89. Manufacturer Standard Lead Time. 10 Weeks. Detailed …
WebK The relative RNA levels of circHIF1A and linear HIF1A were analyzed by qRT-PCR assay after treatment with Actinomycin D in MDA-MB-231 cells. L The relative RNA levels of circHIF1A, linear HIF1A ... WebThe breast cancer cells were used to establish the models in BALB/C nude mice and hypoxia exosomes with circHIF1A shRNA or the controls were injected into the nude …
WebJan 11, 2024 · In support of circHIF1A as a biomarker and target molecule for breast cancer therapy, Zhan and colleagues identified this molecule in a screening of circRNA present in exosomes from hypoxic CAFs in breast cancer . circHIF1A from hypoxic CAFs-derived exosomes proved to be an important player in conferring stem cell properties to breast …
WebcircHIF1A was selectively upregulated in hypoxic breast cancer exosomes specifically.25 Additionally, circHIF1A counteracting miR-580-5p-mediated inhibition on CD44 via sponging miR-580-5p was found to be the mechanism via which CAFs modulated the stemness of cancer cells. The discovery may establish circHIF1A ヴェール 衣装 作り方WebMoreover, circHIF1A could be packaged into exosomes and was upregulated in the plasma of breast cancer patients. Our findings indicated that circHIF1A played a critical role in the growth and metastasis of TNBC via a positive feedback loop and that circHIF1A could be a promising biomarker for breast cancer diagnosis and a potential therapeutic ... ウェアWebJul 28, 2024 · In another study, exosomal circHIF1A significantly promoted triple negative breast cancer growth. An exosomal circHIF1A/NFIB/FUS feedback loop was validated by Chen et al., as exosomal circHIF1A modulated the expression and translocation of NFIB through post-transcriptional and post-translational modification. pagopa cciaa genovaWebJun 14, 2024 · [Cell Death Discovery] Through investigating cellular functions including cell proliferation and stem cell features, it was demonstrated that hypoxic cancer-associated … ヴェール 衣装 通販WebJun 14, 2024 · [Cell Death Discovery] Through investigating cellular functions including cell proliferation and stem cell features, it was demonstrated that hypoxic cancer-associated … pagopa cbill differenzaWebMar 10, 2024 · Epithelial-to-mesenchymal transition (EMT) is a dynamic program of cell plasticity aberrantly reactivated in cancer. The crosstalk between tumor cells and the tumoral microenvironment (TME) has a pivotal importance for the induction of the EMT and the progression toward a malignant phenotype. Notably, exosomes are key mediators of this … ウェアハウス1001xx 縮みWebApr 15, 2024 · CircHIF1A promoted TNBC progression both in vitro and in vivo A (left) Cluster heat map showed the differentially expressed genes in MDA-MB-231 cells with circHIF1A overexpression and control cells. ウェアハウス 1001xx 縮み